MyBioSource.com's RNF20 antibody : AB06/4F9 is a Mouse monoclonal antibody. The RNF20 antibody : AB06/4F9 was generated using RNF20 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
Mouse anti RNF20 antibody recognizes E3 ubiquitin-protein ligase BRE1A, also known as BRE1A. RNF20 is a RING domain E3 ubiquitin ligase and mediates ubiquitin transfer to target proteins. RNF20 plays many roles in transcription, cell division, heat shock responses, and adipogenesis (Jeon et al. 2020). In development, RNF20 is essential for plasticity of embryonic stem cells and controls astrocyte differentiation during brain development (Liang et al. 2018). Alterations in the gene encoding RNF20 have been identified in a variety of human cancers including breast, lung and prostate cancer, clear cell renal cell carcinoma and mixed lineage leukemia. Reduced expression of RNF20 appears to be linked to genome instability, and RNF20 appears to act as a tumor suppressor in cancer types driven by chronic inflammation